Merica Labz Drops an F-BOMB (Excessive Stim Pre-Exercise)

We love the blokes at ‘Merica Labz for doing every part American fashion – which means going huge and pushing the boundaries of conference in the perfect custom of American ingenuity.

To rejoice Black Friday 2022, they’ve actually outdone themselves with an up to date model of F-BOMB, an absolute monster of a stimulant-based exercise whose results will be felt by even probably the most level-headed amongst us. Whereas we love their different pre-workouts like the unique Crimson, White, & BOOM and the fat-burning hybrid NAPALM Crimson, White, & Growth, F-Bomb is for these in search of a bit…truly a lot… extra.

F-BOMB goes to place you excessive on that remaining rep, that final mile, or these previous few dozen bleacher reps – and also you gained’t simply be doing it for your self, you’ll even be doing it for America.

Inside, we’ve bought 473 milligrams of whole caffeine paired with an entire slew of stimulants, together with synephrine, theobromine, and occasional fruit extract. On the pump facet, we’ve Nitrosigine and FitNox put collectively, a mix that’s turning into well-liked. That is no joke and most will wish to do a half-scoop.

Beneath, we element the formulation per the late 2022 launch, which was out in 4 new flavors. The brand new flavors will likely be highlighted in yellow beneath:

In a single 1 scoop (15.1 gram) serving of F-BOMB from ‘Merica Labz, you get the next:

  • Beta-Alanine – 6,400 mg

    Merica Labz F-BOMB November 2022 Label

    The most recent and biggest F-BOMB label, nonetheless with an enormous load of caffeine!

    First we’ve beta-alanine, an endurance-boosting ingredient whose efficacy is so nice that it’s been a typical pre-workout ingredient for over a decade.

    Beta-alanine is an amino acid that mixes with L-histidine, one other amino acid, to provide carnosine, which your physique makes use of to take away lactic acid from muscle tissue.[1] For the reason that buildup of lactic acid in muscle tissue causes muscle mass to really feel fatigue throughout train, eradicating it extra effectively means your muscle mass can work more durable for longer.

    Research on beta-alanine supplementation have repeatedly proven it may enhance total athletic efficiency by rising time to exhaustion[2,3] and energy output,[4] whereas bettering physique composition within the long-run.

    The particular dose utilized in F-BOMB, 6.4 grams per day, is twice the dose that’s been validated as efficaciousby two completely different meta-analyses, which each concluded {that a} mere 3,200 mg advantages the efficiency of any train between 30 seconds and 10 minutes in length.

  • Nitrosigine (as inositol-stabilized arginine silicate) – 1,500 mg

    Nitrosigine is a chemical complicated of the amino acid arginine, the carbohydrate inositol, and potassium silicate,[5] generally referred to by the abbreviation ASI. The purpose of Nitrosigine is to extend the bioavailability of arginine, an amino acid that falls below the class of “semi-essential” or “conditionally important,” which means that though your physique can synthesize some arginine endogenously, it may’t essentially make sufficient to cowl your whole metabolic necessities, notably whenever you’re sick or careworn.[6]

    Arginine is essential to human biochemistry due to its position in nitric oxide (NO) manufacturing. Arginine is an NO precursor, the invention of which led to a long time of makes an attempt to boost NO blood ranges by arginine supplementation. Though marginally efficient, this strategy was finally deemed inefficient on account of arginine’s low oral bioavailability.

    Nitrosigine Working Memory Study

    A brand new research printed in late 2021 confirmed that Nutrition21’s Nitrosigine improves working reminiscence and cognitive perform in wholesome younger adults[15]

    Nitrosigine will increase arginine bioavailability through the use of inositol and potassium silicate to buffer it towards the enzyme arginase,[7] which ordinarily degrades arginine in your abdomen earlier than it may be absorbed by your intestines.[8]

    Nitrosigine does a nice job as a supply car for arginine: supplemental Nitrosigine has been proven to considerably enhance NO manufacturing simply half-hour after ingestion, for a interval of as much as six hours.[9,10]

    Elevated ranges of NO in your blood imply elevated vasodilation, a mechanism that expands your arteries’ diameter to allow a higher throughput of blood.[11]

    Higher circulation implies that oxygen and vitamins get delivered to your cells extra effectively – and waste merchandise get eliminated extra effectively as nicely.

    Each of those results cannot solely enhance athletic efficiency, but additionally pace up restoration following train.[12]

    The added nootropic results of nitric oxide from Nitrosigine

    Nitrosigine Arginine Inositol Silicate

    Not solely does Nitrosigine instantly increase N.O. ranges, it retains them elevated for a interval of as much as 2 weeks!

    Nonetheless, arteries ship blood to your whole physique, so unsurprisingly, elevated NO doesn’t solely have bodily advantages – psychological and cognitive advantages attend increased NO ranges as nicely!

    For instance, Nitrosigine supplementation has been proven to forestall the short-term cognitive impairment that’s usually brought on by intense train.[13]

    However even in non-exercisers, Nitrosigine has been proven to enhance process switching, a measure of cognitive flexibility and multitasking.[14] Newer analysis printed on the finish of 2021 additionally demonstrated enhancements to short-term reminiscence as nicely.[15]

  • L-Tyrosine – 1,000 mg

    Tyrosine normally makes an look in pre-workout formulation as a result of it’s an essential precursor to catecholamine neurotransmitters like dopamine and adrenaline, which most readers are most likely aware of already.[16] By rising your ranges of those neurotransmitters, tyrosine supplementation can set off power mobilization, the discharge of power substrates like glucose and fatty acids into your bloodstream, enabling your cells to take them up and burn them for power.

    Merica Labz F-BOMB November 2022

    Now that’s what you name a wild label

    As a result of adrenaline helps set off the battle or flight response to acute stress, and dopamine is concerned with temper, focus, and motivation, rising catecholamine manufacturing can positively make it easier to get by a tricky exercise, and carry out your finest.

    Tyrosine synergizes nicely with one other ingredient within the F-BOMB formulation, particularly caffeine: whereas tyrosine will increase catecholamine manufacturing, caffeine truly triggers the launch of catecholamines into your bloodstream, the place they flow into all through your physique. The upshot of this one-two punch is considerably elevated temper and elevated power utilization (metabolic fee).[17]

    Tyrosine additionally impacts your physique’s metabolism extra instantly by supporting thyroid hormone manufacturing and rising thyroid perform.[18-20] As an essential precursor to the synthesis of triiodothyronine (T3) thyroxine (T4), tyrosine may also help fight the anti-thyroid results of intense train and calorie restriction,[21,22] one thing that most critical athletes and gymnasium goers have practiced on a semi-regular foundation.

    Tyrosine also can assist handle stress, particularly in sleep-deprived folks.[23] Actually, tyrosine would possibly even be higher at serving to folks deal with fatigue than caffeine,[24,25] which is saying lots!

  • Caffeine Anhydrous – 400 mg (of 473 mg whole caffeine)

    Caffeine is one other pre-workout basic, and for equally good purpose.

    As most of us most likely know, caffeine helps battle fatigue. It does this by inhibiting the motion of adenosine, a metabolic byproduct that builds up in our mind throughout waking hours and produces emotions of tiredness because it accumulates.[26,27]

    Merica Labz Red White & Boom 2021

    An excessive amount of caffeine, however nonetheless need it sturdy? Then attempt the OG Crimson, White, & BOOM Pre Exercise!

    Caffeine’s anti-adenosine impact, which is mediated by caffeine’s capability to block adenosine receptors, is the principle purpose why drained folks the world over attain for that additional mug of tea or espresso…

    However caffeine impacts your physique’s power ranges in different essential methods too. It additionally inhibits phosphodiesterase, the enzyme that breaks down cyclic adenosine monophosphate (cAMP).[26,27]

    As a result of cAMP regulates the speed at which your physique burns carbs and fats for power,[28] increased cAMP ranges imply extra power availability on the mobile degree. Elevating cAMP ranges by phosphodiesterase inhibition is the principle purpose why caffeine has ergogenic properties – it will increase not simply psychological but additionally bodily and athletic efficiency.

    In different phrases, elevated cAMP means the next metabolic fee, and in caffeine’s case, the next fee of fats burning particularly. In accordance with one research, caffeine could enhance your physique’s fee of fats burning by an unbelievable 50%.[29]

    This cannot solely gasoline your exercise, but additionally make it easier to obtain your physique composition objectives sooner by rising the variety of energy you burn day by day!

    Merica Labz Black Friday 2022

    F-BOMB got here out on Merica’s Black Friday 2022 providing. Don’t miss this subsequent 12 months!

    Caffeine is extremely nicely studied, with dozens if not lots of of fantastic peer-reviewed research exhibiting that caffeine consumption can enhance power, endurance, and energy.[30]

    Using caffeine can also have important nootropic results – past merely combating emotions of fatigue, it has been proven to provide sooner response occasions,[31] improved consideration,[31,32] and better alertness.[32]

    Caffeine may additionally enhance working reminiscence,[33] the principle determinant of fluid intelligence that’s recognized to lower as we age.[33]

    Arduous to say sufficient good issues about caffeine – in case you can tolerate it. Not all people can, and over 400 milligrams is a reasonably large dose to take abruptly, so in case you aren’t positive whether or not you’ll be able to deal with it, begin with smaller quantities of caffeine and taper as much as the complete dose.

    That’s sturdy, however now right here’s the place issues get actually enjoyable:

  • Alpha GPC 50% (L-Alpha-Glycerylphosphorylcholine) – 300 mg

    This extremely bioavailable type of choline is able to crossing the blood-brain barrier,[34] which permits it to successfully perform as a precursor to acetylcholine, a neurotransmitter that we regularly name the “studying neurotransmitter” due to how essential it’s for studying, reminiscence, consideration, and application.[35,36] Choline is vital for mind growth,[37] and is a de-facto nootropic ingredient.

    Merica Labz F-Bomb

    However acetylcholine’s capability to advertise interneuronal communication[38] finally ends up affecting extra than simply psychological processes: steadiness and coordination seem like improved by acetylcholine as nicely.[39]

    Though Alpha GPC is a type of choline that’s specialised for mind results, it’s additionally value mentioning that choline is essential for fats burning[40-43] and helps your physique retain dietary carnitine. Carnitine helps your physique burn fats for power.[44-46]

    Not getting sufficient choline is fairly dangerous – it may trigger non-alcoholic fatty liver illness (NAFLD), cognitive dysfunction, and common organ injury.[47-49]

  • FitNox® (as Moringa oleifera Leaf Extract, Punica granatum Extract & Kaempferia parviflora Extract) – 250mg

    FitNox is a plant-based NO booster designed by Glanbia Nutritionals. It consists of three completely different botanical extracts that had been chosen for his or her synergistic impact on NO manufacturing.

    FitNox Benefits Graphic

    FitNox has been proven to precise some important efficiency advantages! Picture courtesy Glanbia Nutritionals

    One 2018 research discovered {that a} 250 mg dose of FitNox is ready to upregulate nitric oxide by a whopping 336% after simply one dose. In that research, the impact lasted for 10 hours or extra![50]

    In one other research, topics who took 250 mg of FitNox for 22 days not solely had increased NO ranges, but additionally had longer time to exhaustion and decrease ranges of compounds that induce muscular fatigue.[51] On this research topics had been additionally discovered to have increased dopamine ranges,[51] which is a boon for motivation and focus, and may positively make it easier to adhere to a difficult vitamin and health routine.

    The mechanism of motion behind FitNix is upregulation of nitric oxide synthase, the enzyme that your physique makes use of to provide NO.

  • Dicaffeine Malate – 100 mg (yields 73 of 473 mg whole caffeine)

    Dicaffeine malate has the same old results of caffeine,[52-55] however a special power curve: it acts slower and over an extended time period than caffeine anhydrous.

    This naturally results in a gentler buzz with out almost as a lot of an power crash because the caffeine inevitably wears off.

    The rationale this occurs is the malic acid molecule sure to the caffeine acts as a type of digestive buffer, mainly slowing down your physique’s absorption of the caffeine molecule.

    Stacking dicaffeine malate with caffeine anhydrous may also help provide the better of each worlds: fast-acting anhydrous for a right away increase, plus the malate type to assist handle withdrawals.

    Word that this brings our caffeine whole as much as 473 milligrams – a not small dose – since dicaffeine malate is about 73% caffeine by weight.

  • CognatiQ (Entire Espresso Fruit Extract) (Coffea Arabica) – 100 mg

    Previously referred to as NeuroFactor, CognatiQ is a espresso fruit developed with focus and cognition in thoughts. It really works by rising brain-derived neurotrophic (BDNF) expression.[56] BDNF is a protein that helps the upkeep, progress, and total survival of neurons within the mind.[57,58] It helps regulate neuroplasticity (the power for the mind to reply and reshape when studying) within the hippocampus, the positioning of long-term potentiation (LTP).[59]

    Glaxon Neuro 365 Coffee Berries BDNF Supplement Extract

    Unroasted espresso berries – the supply of CognatiQ

    Analysis has proven a robust correlation between cognitive efficiency and excessive BDNF ranges within the blood.[57-62] Actually, increased ranges of BDNF appear to assist defend the mind from neurodegenerative ailments,[57,58,61,62] whereas low ranges enhance the chance for such sicknesses.[62]

    When boosting BDNF, we regularly see improved cognitive efficiency, however have additionally seen a lift in cardio train as nicely![60]

    A analysis research confirmed {that a} 100-milligram dose of espresso fruit extract — what we’ve right here in F-BOMB — can increase BDNF ranges within the blood by almost 150%![56]

    We’ve additionally seen, anecdotally, that dietary supplements with NeuroFactor / CognatiQ merely really feel higher. Nice to have it right here.

  • Theobromine – 100mg

    One among caffeine’s three main metabolites, theobromine is one other methylxanthine, however with longer-lasting, milder results than caffeine. This may increasingly assist the power from F-BOMB stick round longer… as if we wanted extra methylxanthine assist!

    Theobromine has analysis backing its use as an anti-inflammatory ingredient, urge for food suppressant, and may present cardioprotective results.[63,64]

    Theobromine Effects

    Attention-grabbing: Excessive-Dose Theobromine can dial up the “feels”.[65]

    Like caffeine, theobromine inhibits adenosine and phosphodiesterase.[63] It’s milder, however longer-lasting, with a higher half-life than caffeine.[65]

    We regularly wish to cite a research that found that theobromine will increase rankings of really feel for customers.[65] And that’s what the ‘F’ in F-BOMB stands for…. proper??

  • Synephrine HCl – 30 mg

    Synephrine is a robust beta agonist that targets the beta-3 adrenoceptor greater than the beta-2 one,[66] resulting in some potent energetic and thermogenic results.

    Synephrine vs. Higenamine

    Synephrine is a a lot faster beta-agonist than Higenamine, one other frequent ingredient in fats burner dietary supplements.

    Particularly, synephrine does an amazing job binding to the beta-3 adrenergic receptors in your physique’s adipose (fats) tissue,[66] which, once more, prompts the cyclic adenosine monophosphate (cAMP) cascade and will increase your physique’s capability to burn glucose and fats for power.[67]

    Curiously, the beta-3 adrenergic pathway appears to have a lot much less of an impact on coronary heart fee of blood strain, in comparison with the beta-2 adrenergic pathway,[66] which means there’s much less cardiovascular draw back to utilizing synephrine.

    Synephrine additionally, unsurprisingly, will increase basal metabolic fee and reduces urge for food,[66] making it one other nice ergogenic stimulant.

    In a single double-blind, placebo-controlled research from 2016, topics who supplemented with synephrine burned considerably extra fats throughout their exercise than those that bought a placebo.[68]

    A 2015 research discovered that combining synephrine and caffeine – which F-BOMB does – offered a fair higher enhance in fats oxidation than different ingredient alone.[69]

    Apart from the whopping dose of caffeine, that is actually the ingredient that places the ‘F’ in F-BOMB!

  • Huperzia serrata Extract (leaf and stem) (1% Huperzine A) – 10 mg

    Huperzine A, like alpha-GPC, is right here due to its results on the acetylcholine system.

    Merica Labz NAPALM Red White & Boom

    Want extra fats burning assist? The thermogenic Merica Labz NAPALM Crimson White & Growth pre-workout is again, and this time with a brand new Agent Blue taste!

    Whereas acetylcholine precursors like alpha-GPC enhance acetylcholine manufacturing, huperzine A helps increase your acetylcholine ranges by inhibiting the enzyme acetylcholinesterase, which is liable for breaking down acetylcholine.[70]

    This mainly implies that your acetylcholine ranges fall extra slowly, and keep elevated longer thus amplifying the consequences of the alpha-GPC in F-BOMB.

    Huperzine A works nicely sufficient at retaining acetylcholine ranges excessive that huperzine A by itself considerably improves cognition and studying.[71]

    Huperzine A additionally has antioxidant properties, and helps defend the mitochondria in your neurons from free radicals.[72]

  • Go away it to ‘Merica to provide you with some colourful taste names, with much more colourful imagery close to every one:

    Those in yellow above are the brand new flavors launched on Black Friday 2022. Different flavors, if obtainable, will likely be gone quickly, so seize them whilst you can

    F-BOMB lives as much as its title – this can be a really explosive formulation completely jam-packed with stimulants and pump brokers to present you a enormous burst of power in your hardest exercises.

    Stimmed up formulation work very well for some folks – for different folks, not a lot. What provides one particular person a clear, sustainable buzz would possibly give one other the jitters and maintain him up at evening.

    Finally, as with the rest, solely you are liable for assessing your tolerance. Should you’ve by no means taken synephrine, for instance, begin with a partial scoop of F-BOMB and work your means as much as a full scoop.

    In fact, if you’ll want to tone it down from Merica Labz, try Crimson, White, and BOOM or NAPALM Crimson, White, and Growth. Should you couldn’t inform, alongside Merica Vitality, this type of product line is the way forward for Merica Labz.